Naltrexone

About naltrexone

Naltrexone  is a strong and highly specific opiate antagonist.

Naltrexone binds to opiate receptors and prevents from penetration of heroin, methodon, codeine, dentoxile and other opiates thereto. Owing to this effect opiates administrated in the body do not produce their specific effect (euphoria, miotic pupils etc.).

Thus, patient taking Naltrexone in doses prescribed by doctor cannot have narcotic intoxication if takes heroin or other opiates in.   

Usual administration regime of Naltrexone is 1 tablet (50 mg) 1 times a day. Other administration regimes are also possible: 2 tables every other day or 3 tablets one time every third days.

Clinical studies prove safe administration of Naltrexone in the above-mentioned doses. Naltrexone does not provoke dependence or any addiction.

Usual duration of Naltrexone therapy is 1 year. Minimum duration is 6 months.

Contraindications:

Attention: Attempted intake of heroin or other opiates during treatment with Naltrexone may lead to overdosing and death.

If you have passed detoxication course and administrated Naltrexone for some time, Your resistance to opiates reduced much. So called “usual doses” may lead to death!

Administration of Naltrexone to patients not passed detoxication causes during 5-20 minutes extremely heavy manifestations of abstinence: nausea, vomiting, convulsions, muscle pains, aches in waist and joints, tachycardia, cardiac rhythm impairment. Acute psychosis is possible.

Sometimes, these manifestations are so much pronounced that it becomes necessary to hospitalise a patient to the department of intensive care.

Mechanism of action of naltrexone

Naltrexone belongs to a group of drugs known as opioid antagonists. Its main mechanism is to block opioid receptors in the brain. When these receptors are blocked, the euphoric and sedative effects typical of opioid use, as well as the effects of alcohol, are reversed. This receptor blockade makes Naltrexone effective in reducing the motivation to use these substances.

With respect to alcohol dependence, the precise mechanism by which naltrexone reduces drinking behavior is thought to involve modulation of the dopaminergic mesolimbic pathway, often referred to as the “ayreward pathway”. By reducing the pleasure associated with alcohol, Naltrexone helps reduce cravings and cravings for alcohol.

Benefits of using Naltrexone

By blocking opioid receptors, Naltrexone significantly reduces cravings for opioids and alcohol. Especially in the case of opioids, Naltrexone can prevent the euphoric effects of these substances, thereby reducing the risk of relapse. Unlike some other treatments, such as Methadone, Naltrexone does not require detox before starting treatment.

Naltrexone plays a very important role in the treatment of both alcohol and opioid addiction. It is an effective treatment when combined with other therapeutic strategies, such as therapy that addresses addictive behaviors and triggers. The use of naltrexone represents a significant advance in addiction medicine, providing a valuable tool for individuals struggling to overcome alcohol and opioid addiction.